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In , this country of 46 million people wowed more than 76 million tourists with sunshine, tapas, culture and color. Choosing one area to focus on can mean exploring more deeply and getting a small sense of what has made this dynamic country a tourist favorite for centuries. But where should you begin, and why? To answer those questions, learn about some of the top attractions in Spain and where to find them. On its north end, it borders the Atlantic Ocean and the Bay of Biscay. Heading east takes you to Malaga and Andalusia and up into the tourist hot spots of Costa Brava and Barcelona before the French Riviera after you cross the border with France. At the narrowest point of the Strait of Gibraltar, Spain is just 8. When in Spain, inter-city travel is also quite easy, thanks to excellent commuting options like the high-speed trains that take travelers from Barcelona to metropolitan Madrid in just three hours. The Prado celebrates its th anniversary in , which is also when it will open a new section that adds 16 percent more space for the collections.

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Overview[ edit ] Since , archaeologists have been working at numerous areas of the Archaeological Site of Atapuerca , where they have found ancient hominid and human remains, the former dating to more than one million years ago, with artefacts from the Palaeolithic and Bronze Ages of man. The other locations higher than 20, inhabitants apart from Burgos are Miranda de Ebro and Aranda de Duero , both very industrialized.

Planted near it is a notable vineyard , Ribera de Duero. The north and south-east of the province are mountainous. The Ebro flows to the Mediterranean Sea. In Valpuesta the oldest texts in the Spanish language has been found, dating from the tenth century.

DNA evolution models made invaluable contributions to comparative genomic studies. Still lacking is an evolutionary model of transcription networks (TNs).

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After ligand binding, the intracellular domain translocates to the nucleus and activates transcription factors. The Notch signaling pathway plays a central role in the development and maturation of most vertebrate organs, with pleiotropic effects depending on dose and context summary by Monet-Lepretre et al. The authors narrowed the critical region to a small interval bracketed by D19S centromerically and D19S telomerically. The investigators constructed YAC and BAC contigs encompassing the critical region, the size of which was estimated to be approximately kb.

Of the candidate transcripts identified through direct selection of cDNA, one showed strong homology with the 5-prime-coding end of the mouse Notch3 gene. They assembled a contiguous stretch of 5, bp of human NOTCH3 coding sequence that was highly homologous to its murine coding counterpart.

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On one side of it stands the City Hall , an eclectic building dating from the beginning of the 20th century, crowned by a clock tower. The Museum of Valladolid occupies this complex, exhibiting a collection of furniture, sculptures, paintings and ceramic pieces dated from Prehistoric times to the present. The Teatro Lope de Vega is a theater built in the classical style in and now very run-down. There has been controversy over whether the city should pay to restore it.

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